The Lin lab is seeking molecular biologist to work in an interdisciplinary team environment on understanding how gene regulation is altered in cancer. This position will involve supporting ongoing research in the lab and will include molecular cloning, basic molecular biology techniques, and assisting with maintaining lab stocks, reagents, equipment and common spaces. Individuals with strong communication and organizational skills with a desire to pursue careers in life sciences are encouraged to apply.
- Work under the supervision of molecular biologists to design recombinant DNA constructs for cell line engineering
- Generate recombinant DNA constructs via molecular cloning techniques including standard restriction
- Gateway and Gibson technologies
- Perform nucleic acid and protein extractions from mammalian cell lines
- Perform nucleic acid quantification techniques including gel electrophoresis and real-time PCR
- Perform mammalian cell culture
- Experience with lab ordering and inventory systems
- Maintain laboratory stocks, equipment and common spaces
- Clearly communicate and document (oral and written) experimental results and progress.
Required: Bachelor's degree in a basic science or equivalent work experience.
Preferred: Prior experience in molecular biology laboratory.
- Expertise in molecular cloning.
- Experience with lab ordering and inventory systems.
- Prior experience in a molecular biology laboratory is strongly preferred.
The Lin lab studies cancer through the lens of gene control — the way in which genes in the genome are selectively and programmatically turned on and off. Altered gene control is a hallmark of cancer and we apply computational, molecular, and chemical biology approaches to better understand this process and how it affects tumor cell growth. We believe that targeting the gene control machinery is a novel, potent and feasible way to block the final common pathway of oncogenic signaling across a range of cancers.
Dr. Lin is a Pew-Stewart Scholar for Cancer Research, an Assistant Professor in the Department of Molecular and Human Genetics, and the Co-director of the Therapeutic Innovation Center at Baylor College of Medicine. He is a leader in the study of the “MYC” oncogene, the most commonly amplified human oncogene, and helped uncover its role as a general amplifier of transcription. Through his work he has also helped describe super-enhancers, control regions of the genome that activate oncogenes and can be selectively targeted by small molecules targeting chromatin and transcriptional regulators. Prior to joining the Baylor College of Medicine, Dr. Lin trained at the Dana-Farber Cancer Institute and earned his Ph.D. in Computational and Systems Biology from the Massachusetts Institute of Technology.
This position provides the opportunity to work alongside experts in many disciplines on projects directly connected to clinical data and pre-clinical modeling. As such, communication skills and the ability to work well in a team setting will be highly emphasized. Candidates will have the opportunity to contribute to research projects and to gain authorship on research manuscripts. As the laboratory serves as an academic training environment, recent undergraduates seeking research experience and mentorship prior to applying for graduate or medical school are strongly encouraged to apply.