A postdoctoral position is immediately available in the laboratory of Dr. Jonathan Flanagan in the Department of Pediatrics at Baylor College of Medicine in Houston, Texas. The research will focus on determining the molecular mechanisms underlying the pathophysiology of sickle cell anemia. The successful candidate will employ the results of our laboratory's highly-innovative functional genomics technologies toward discovery of genetic modifiers of sickle cell anemia. Specifically, the individual will assess the functional activity of mutations identified in large scale next generation sequencing efforts, by investigating the mechanistic roles of identified genes using cell culture and mouse model systems. The goal of this work will be to establish which genetic modifiers contribute most to the clinical outcome of sickle cell anemia and to determine if these modifiers could potentially improve the treatment of patients with sickle cell anemia.
- Must have a peer-reviewed publication record, and possess a strong background in genetics and cell/molecular biology.
- Experience in cloning, design and production of viral vectors, gene silencing, functional cell assays (e.g., cell survival, proliferation, growth assays) and basic bioinformatics experience.
- Successful candidates will be expected to tackle challenging scientific problems, develop and optimize functional assays using up to date technologies, and contribute to the positive and energetic work environment of our laboratory.