AgenTus Therapeutics is a dynamic new start-up subsidiary developing T cell receptors (TCRs) and chimeric antigen receptors (CARs) designed to supercharge human immune effector cells to seek and destroy cancer. We aim to deliver cures to cancer patients around the world by leveraging our proprietary platforms for TCR discovery, targeting novel phosphopeptide neo-epitopes and developing unique allogeneic cell therapies. Together with our parent company, Agenus, we have a deep and diverse repertoire of immunotherapy treatments that can be used in combinations that will synergize to help the body’s immune system fight cancer.
The successful candidate will have a strong background in cell biology, immunology, molecular biology and/or oncology research. He/She will work closely with discovery scientists on the production of recombinant cell lines and gene expression constructs to advance research stage programs into early clinical development, providing both scientific and technical expertise. The successful candidate is expected to have experience in a range of cell biology techniques including: multi-parameter flow cytometry, cell culture, transfections and functional assay development, and experience in general molecular/biochemical methods. Experience with lentiviral systems is a plus. He/she is expected to design, plan and execute experiments both independently and as part of multidisciplinary team of researchers. The successful candidate will have the ability to interpret results, troubleshoot technical hurdles and propose solutions to the team. He/she will be also expected to contribute to the preparation of technical documents, project report summaries, laboratory protocols and other compliance documents.
Additional roles and responsibilities:
· Carefully plan and execute experimental work in an organized manner within agreed timelines
· Coordinate and supervise the work of other research associates
· Contribute to the continual improvement of research protocols within the group
· Seek to optimize and standardize current assay protocols, and propose/evaluate alternative assays/methodologies/technologies
· Keep abreast of current research literature related to their project(s)
Qualifications: We are seeking an individual who is enthusiastic, self-motivated and has excellent problem solving and communication skills. Applicants should have at least a MS degree in immunology, oncology, molecular biology or related field. Evidence of an understanding in the principles and techniques employed to characterize antibody-based cancer therapies is highly preferred. He/She should be a self-motivated team player. Attention to detail, and the ability to maintain clear and accurate research documentation are a key requirement. Excellent written and oral communication skills are required for this position, and he/she is expected to provide clear/concise data summaries in a variety of project team forums.